Leptomeningeal capillary malformation levels linked to epilepsy severity in Sturge-Weber syndrome


  • Greater extent of leptomeningeal capillary malformation is linked to more severe epilepsy seizures and cognitive deterioration in Sturge-Weber syndrome.

Why this matters

    Seizures affect most people with Sturge-Weber syndrome, and around 50% are refractory to antiepileptic drugs. This novel study reports that more extensive leptomeningeal capillary malformation and frequent seizures are key indications for surgery. The findings support regular clinical follow-up after initial diagnosis to identify those with frequent seizures who are most likely to benefit from surgery.