Perivascular space enlargement due to reduced clearance via arterioles: a key factor in cerebral amyloid angiopathy and Alzheimer’s disease?

Abstract

Perivascular spaces (PVS) are compartments surrounding cerebral blood vessels that become visible on MRI when enlarged. Enlarged PVS (EPVS) are commonly seen in patients with cerebral small vessel disease (CSVD) and have been suggested to reflect dysfunctional perivascular clearance of soluble waste products from the brain.