Risk factors for opioid-related harms in people with chronic non-cancer pain


  • In addition to opioid dose, younger age, substance dependence and mental health problems are associated with problematic opioid use behaviors in people with chronic non-cancer pain (CNCP).

Why this matters

  • Long-term opioid prescribing for people with CNCP has increased significantly over the past twenty years and has led to increased opioid-related harms.

  • This prospective, long-term, comprehensive cohort study identified several independent risk factors associated with problematic opioid use and highlighted the need for a holistic and individualized approach in the assessment and treatment of people with CNCP.

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